Key points of the concept
- a structurally diverse small molecule natural product library encompassing pure compounds from plants of geographically distant and megadiverse regions, to serve as a quick entry to scaffolds of potential interest for the cosmetic and agricultural applications sought
- a focused library of plant extracts assembled on the basis of chemodiversity and chemotaxonomy considerations, originating from plants from hotspots of biodiversity and endemism, to provide sub-libraries of compounds around the shortlisted scaffolds
- efficiency and traceability due to a high degree of standardization, automation and miniaturization in the generation and management of libraries, screening, and in profiling thanks to the development of a common platform for management and use of sample related spectral data and metadata.
- use of relevant in vitro assays for major areas of use in cosmetics and as agrochemicals
- stringent prioritization mechanisms for progressing samples
- accelerated purification of active compounds thanks to optimised isolation procedures
- development with scale-up isolation and advanced testing
- expert monitoring of issues related bioprospecting and sustainability
- complementary expertise available at the different partners of the consortium
Key objectives
- Discovery and characterization of novel plant derived small molecule-type natural products which qualify as development candidates for new cosmetic and agrochemical agents with innovative or improved properties
- Establishment of screening libraries with an unprecedented level of library-related spectroscopic information and metadata
- Development of new concepts for integrating information contents with screening libraries
- Enhancing the competitiveness of European cosmetic and agrochemical industry through discovery of novel compounds for development
- Opening new potentialities for the development of natural products derived from economically less favored but megadiverse regions, for sustainable production of products with high consumer acceptance
